Bremelanotide – PT-141 – Clinical Studies and Research

Phase I Randomized Placebo-controlled, Double-blind Study of the Safety and Tolerability of Bremelanotide Coadministered With Ethanol in Healthy Male and Female Participants. Clin Ther. 2017 Mar;39(3):514-526.e14. doi: 10.1016/j.clinthera.2017.01.018. Epub 2017 Feb 9.PMID: 28189361
Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Clayton AH, Althof SE, Kingsberg S, DeRogatis LR, Kroll R, Goldstein I, Kaminetsky J, Spana C, Lucas J, Jordan R, Portman DJ. Womens Health (Lond). 2016 Jun;12(3):325-37. doi: 10.2217/whe-2016-0018. Epub 2016 May 16.
The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.Kingsberg SA, Clayton AH, Pfaus JG.CNS Drugs. 2015 Nov;29(11):915-33. doi: 10.1007/s40263-015-0288-1.PMID: 26519340
Drugs in early clinical development for the treatment of female sexual dysfunction.Belkin ZR, Krapf JM, Goldstein AT.Expert Opin Investig Drugs. 2015 Feb;24(2):159-67. doi: 10.1517/13543784.2015.978283. Epub 2014 Nov 6. Review.PMID: 25376023
Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies.Ückert S, Bannowsky A, Albrecht K, Kuczyk MA.Expert Opin Investig Drugs. 2014 Nov;23(11):1477-83. doi: 10.1517/13543784.2014.934805. Epub 2014 Aug 6. Review.PMID: 25096243
Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.Safarinejad MR, Hosseini SY.J Urol. 2008 Mar;179(3):1066-71. doi: 10.1016/j.juro.2007.10.063. Epub 2008 Jan 18.PMID: 18206919
Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study.Safarinejad MR.J Sex Med. 2008 Apr;5(4):887-97. doi: 10.1111/j.1743-6109.2007.00698.x. Epub 2007 Dec 28.PMID: 18179455
Melanocortins in the treatment of male and female sexual dysfunction.Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ.Curr Top Med Chem. 2007;7(11):1137-44. Review.PMID: 17584134
Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB.Int J Impot Res. 2004 Apr;16(2):135-42.PMID: 14999221