Clinical Studies

Anti Ageing

  • Savine, R., et al., “Growth hormone replacement for the somatopause,” Horm Res 2000; 53(Suppl 3):37- 41.
  • Simpson, H., et al., “Growth hormone replacement therapy for adults: into the new millennium,” Growth Hormone & IGF Research 2002; 12:1-33
  • Peter H Sonksen, MD, Growth Hormone & IGF-1 Research 1998, 8, 275-276
  • Bartke, A., List, E., & Kopchick, J. (2016). The somatotropic axis and aging: Benefits of endocrine defects. Growth Hormone & IGF Research, 27, 41-45. doi:10.1016/j.ghir.2016.02.002

Increased Energy

  • Chikani, Viral (2017). The role of growth hormone in the regulation of the anaerobic energy system and physical function. PhD Thesis, School of Medicine, The University of Queensland. https://doi.org/10.14264/uql.2017.446
  • Skin Tightening, Increased Elasticity
  • Póvoa, Guilherme, & Diniz, Lucia Martins. (2011). Growth Hormone System: skin interactions. Anais Brasileiros de Dermatologia, 86(6), 1159-1165. https://dx.doi.org/10.1590/S0365-05962011000600015

Libido Enhancement

  • Becker AJ, e. (2018). Serum levels of human growth hormone during different penile conditions in the cavernous and systemic blood of healthy men and patients with erecti… – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/11927337

Build Lean Muscle

  • Velloso, C. (2008). Regulation of muscle mass by growth hormone and IGF-I. British Journal Of Pharmacology, 154(3), 557-568. doi:10.1038/bjp.2008.153
  • Tavares, A. B., Micmacher, E., Biesek, S., Assumpção, R., Redorat, R., Veloso, U., Vaisman, M., Farinatti, P. T., … Conceição, F. (2013). Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old. International journal of endocrinology, 2013, 942030.
  • Margareta Hedström, Maria Sääf, Eva Brosjö, Carolin Hurtig, Kerstin Sjöberg, Ann Wesslau & Nils Dalén (2004)Positive effects of short-term growth hormone treatment on lean body mass and BMC after a hip fracture A double-blind placebo-controlled pilot study in 20 patients, Acta Orthopaedica Scandinavica, 75:4, 394-401, DOI: 10.1080/00016470410001141-1

Fat Loss

  • Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-9.
  • Ng FM, e. (2018). Metabolic studies of a synthetic lipolytic domain of GH. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 10 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/11146367
  • Ho KK, e. (2018). Metabolic actions of growth hormone in man. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/9076343
  • Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., & Björntorp, P. et al. (1997). Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass, Improves Glucose and Lipoprotein Metabolism, and Reduces Diastolic Blood Pressure. The Journal Of Clinical Endocrinology & Metabolism, 82(3), 727-734. doi:10.1210/jcem.82.3.3809
  • Michael Højby Rasmussen. Obesity, growth hormone and weight loss. Molecular and Cellular Endocrinology, Elsevier, 2009, 316 (2), pp.147. 10.1016/j.mce.2009.08.017
  • KS, C. (2018). Acute growth hormone effects on amino acid and lipid metabolism. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/8175957
  • Vijayakumar, A., Novosyadlyy, R., Wu, Y., Yakar, S., & LeRoith, D. (2009). Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 20(1), 1-7.
  • Berneis, K., & Keller, U. (1996). Metabolic actions of growth hormone: direct and indirect. Baillière’s Clinical Endocrinology And Metabolism, 10(3), 337-352. doi:10.1016/s0950-351x(96)80470-8
  • Møller, N., & Jørgensen, J. (2009). Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects. Endocrine Reviews, 30(2), 152-177. doi:10.1210/er.2008-0027
  • Nam, S., et al., “Growth hormone and adipocyte function in obesity,” Horm Res 2000; 53(Suppl 1):87-97)
  • Weaver, J., Monson, J., Noonan, K., John, W., Edwards, A., Evans, K., & Cunningham, J. (1995). The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. The Journal Of Clinical Endocrinology & Metabolism, 80(1), 153-159. doi:10.1210/jcem.80.1.7829604
  • Kim KR, e. (2018). Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dys… – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/10352397
  • Nam, S., et al., “Growth hormone and adipocyte function in obesity,” Horm Res 2000; 53(Suppl 1):87-97)
  • Weaver, J., Monson, J., Noonan, K., John, W., Edwards, A., Evans, K., & Cunningham, J. (1995). The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. The Journal Of Clinical Endocrinology & Metabolism, 80(1), 153-159. doi:10.1210/jcem.80.1.7829604
  • Kim KR, e. (2018). Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dys… – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/10352397
  • Traditional and novel aspects of the metabolic actions of growth hormone Sperling, Mark A. Growth Hormone & IGF Research , Volume 28 , 69 – 75

Injury Repair

  • Papadakis MA, e. (2018). Effect of growth hormone replacement on wound healing in healthy older men. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/17309692
  • Schmidmaier, G., Wildemann, B., Heeger, J., Gäbelein, T., Flyvbjerg, A., Bail, H., & Raschke, M. (2002). Improvement of fracture healing by systemic administration of growth hormone and local application of insulin-like growth factor-1 and transforming growth factor-β1. Bone, 31(1), 165-172. doi:10.1016/s8756-3282(02)00798-6

Improved Sleep

Improved Cognition

  • Lasaite L, e. (2018). Psychological functioning after growth hormone therapy in adult growth hormone deficient patients: endocrine and body composition correlates. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/15299990
  • Nyberg, F., et al., “Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance,” Frontiers in Neuroendocrinol 2000; 21(4):330-348
  • Takako Niikura et al. Insulin-Like Growth Factor 1: IGF-1 Protects cells from Apoptosis by Alzheimer’s V6421 Mutant Amyloid Precursor Protein through IGF-1 Receptor in an IGF-Binding Protein-Sensitive Manner. The Journal of Neuroscience, March 15, 2001, (21(6):1902-1910)

Bone Health

  • Sugimoto, T., et al., “Effect of recombinant human growth hormone in elderly osteoporotic women,” Clin Endocrinol (Oxf) 1999; 51(6):715-124
  • Baum, H., et al., “Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial,” Ann Intern Med 1996; 125(11):883-90)
  • RC, O. (2018). Regulation of bone mass by growth hormone. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 7 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/12868124
  • Elbornsson, M., Gotherstrom, G., Bosaeus, I., Bengtsson, B., Johannsson, G., & Svensson, J. (2012). Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency. European Journal Of Endocrinology, 166(5), 787-795. doi:10.1530/eje-11-1072
  • Gillberg P, e. (2018). Two years of treatment with recombinant human growth hormone increases bone mineral density in men with idiopathic osteoporosis. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 15 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/12414848
  • Landin-Wilhelmsen K, e. (2018). Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial. – PubMed – NCBI . Ncbi.nlm.nih.gov. Retrieved 15 November 2018, from https://www.ncbi.nlm.nih.gov/pubmed/12619921

Heart Health

  • Ren, J., et al., “Insulin-like growth factor 1 as a cardiac hormone: physiological and pathophysiological implications in heart disease,” Journ Mol Cell Cardiol 1999; 31(11):2049-61

Improves Immune System

  • Burgess, W., et al., “The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-1,” Neuroimmunomodulation 1999; 6(1-2):56-68