GHRP-2

GHRP-2 is considered one of the mildest GHRP’s next in line to Ipamorelin. GHRP-2 is a hexapeptide and a pure growth hormone secretagogue. It is also a synthetic agonist of the hormone Ghrelin.
Molecular Mass: 817.9749 g/mol
Molecular Formula: C45H55N9O6
Molecular Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2

GHRP-2 is a growth hormone releasing peptide and is a single polypeptide chain composed of six amino acids. A hexapeptide, GHRP-2 stimulates ghrelin release and works to correct deficiencies in growth hormone. Since GHRP-2 is a ghrelin agonist, it helps influence HGH secretion in two ways. For one, it acts to boost GH levels by amplifying the transduction pathway. It also suppresses the action of a hormone called somatostatin which blocks growth hormone release. These activities make GHRP-2 a perfect option from which one can increase growth hormone levels.

GHRP is short for “Growth hormone releasing peptides”. These are a family of peptides acting upon the hypothalamus and the pituitary gland. They release growth hormones through the activation of a particular protein receptor. First identified two decades ago, GHRP’s are a synthetic tissue made up from amino compounds. GHRPs have no structural similarity with one’s natural or endogenous growth hormone-releasing hormone aka GHRH.

The most significant side effect experienced by patients using GHRP-2 is tied to increased hunger, but do note that this increase in appetite is minimal. It does still offer the benefits of ghrelin activation. Ghrelin’s importance is in the fact that it is a regulator of GH secretion and it is one that is produced within the stomach, influenced greatly by the patient’s diet and nutrient quota. Clinical studies have linked an increase of ghrelin to fasting and one’s anticipation of meals. With GHRP-6 this is why the hunger experienced can be considered somewhat extreme, for the peptide can mimic ghrelin effects. With GHRP-2, this side effect has been reduced by chemists, so that the hunger is not as severe. Patients should be aware that GHRP-2 does elevate cortisol and prolactin – particularly if a patient is dosing within the higher ranges of over 200mcg. Another side effect that is common among users starting out on GHRP-2 is a feeling of lethargy.
Other side effects of GHRP-2

• Elevates Cortisol and Prolactin
• Feeling Tired or Lethargic upon onset of GHRP-2 use
• Water retention
• Tingling and numbness
• Decreased insulin sensitivity