What is GHRP-6?
Effectively increases the levels of one’s natural HGH secretion in the body. GHRP-6 can also promote an increase in body mass whilst bringing about a significant reduction in body fat. GHRP-6 is a synthetic met-enkephalin analogue that includes unnatural D-amino acids, developed for growth hormone releasing activity. Works at the Ghrelin receptor. GHRP-6 (also called pralmorelin) is considered a synthetic growth hormone secretagogue made of six amino acids. It has a short half-life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration. Potent in its stimulation of growth hormone release, GHRP is slightly more potent than Ipamorelin.
Molecular Weight: 873.01Da
Molecular Formula: C45H56N12O6
Molecular Weight: 873.01Da
Molecular Formula: C45H56N12O6
The discovery of GHRP’S – What is a GHRP?
GHRP is short for “Growth hormone releasing peptides”. These are a family of peptides acting upon the hypothalamus and the pituitary gland. They release growth hormones through the activation of a particular protein receptor. First identified two decades ago, GHRP’s are a laboratory made metenkephalin derived oligopeptides. In laymans terms this means a synthetic tissue made up from amino compounds. It is important to understand that GHRPs have no structural similarity with one’s natural or endogenous growth hormone releasing hormone aka GHRH.
Benefits of GHRP-6
- Promotes lean muscle mass
- Reduced fat mass
- Speeds up the healing of wounds and injuries
- Appetite Stimulation
- Increased Cellular Repair and Regeneration
- Increased Bone Density
- Improved Quality of Sleep
- Reduction in skin wrinkling and improves the skins elasticity
- Increased libido
- Boosts endurance, energy and vitality
- Strengthens the immune system
- May improve memory and cognitive function
Effects of GHRP-6
- Stimulates the body's secretion of hGH
- Increased IGF-1 Production
- Increased Collagen Production
- Increases protein synthesis
- Stimulates the hypothalamic area of the brain
- Promotes lipolysis
- Increases calcium retention
- Promotes glucogenesis in the liver
- Decreases uptake of glucose in the liver.
- Treats growth hormone deficiency
- Treatment doesn’t affect prolactin and cortisol
- No Desensitisation
GHRP-6 peptide – How it works
GHRP-6 stimulates the anterior pituitary gland. This, in turn, results in an increased release of growth hormones in the body. Since GHRP-6 directly affects the feedback loop, this triggers alterations that inhibit the release of GH. GHRP-6 it can be used to restore the natural manufacturing of Growth Hormone, particularly if natural secretion has been impaired due to long-term artificial supplementation. GHRP-6 also impacts our nervous system, protecting neurons and increasing the strength of the user. GHRP-6 is a compound with a unique chain that has 6 amino acids that are responsible for telling our body when to start releasing HGH. Extensively used to treat growth hormone deficiency along with other complications like obesity, cachexia, and eating disorders. GHRP-6 is used primarily by those who want to gain body mass and need the increased hunger to correct their energy metabolism. GHRP-6 is a newer drug on the market, but it has quite an appeal, particularly to those looking for performance enhancement. As an anti-inflammatory agent, GHRP-6 protects the muscle, which is crucial in the muscle recovery process and synthesis. GHRP-6 ensures that the liver is capable of initiating the IGF-1 secretions. This will help patients lose fat much more quickly as well as gain strength with each new day. Researchers suggest that the effectiveness of growth hormones does depend on the physical condition of the patient. Obese patients may not reach their desired hormonal secretion. GHRP-6 use has been shown to lower fat, making it an excellent peptide for bodybuilders during their cutting cycles. GHRP-6 facilitates the increase and development of muscles. It increases one’s stamina levels post administration of GHRP-6. Like Ipamorelin, GHRP-6 doesn’t affect prolactin nor cortisol release so long as the doses are kept under 100mcg. When treatments are above 100mcg, the effect on prolactin and cortisol release is minimal, and there should be no need for concern. No de-sensitisation to its effectiveness, so long as one spaces out their doses two hours or more. Like ghrelin, GHRP-6 it does increase hunger rather significantly, this usually occurring within 30 minutes of its administration. Though not a prevalent side effect, some people experience stomach discomfort with GHRP-6. Saturation dose is around 100mcg, meaning that doses above this level have declining effectiveness. It has been found in studies that it may also increase muscle growth (Penalva 1993).
GHRP-6 Side effects
Like all other steroidal drugs, GHRP-6 has a few side effects, which is why patients must follow the strict dosing schedule provided by our hormones specialist. By doing so, you not only protect your endogenous growth hormone stimulation, but you minimise the potential for experiencing side effects. The most common side effect reported by users is the increase in appetite. All GHRP’s are known to escalate hunger. Thus GHRP-6 is no exception. Studies indicate that GHRP-6 has the highest potential to cause an appetite increase. This increased hunger will subside once the patient has consumed an appropriate meal. Patients do find that this desire to eat gradually diminishes through use, but it does not go away entirely and will remain throughout the entire cycle of administration.
Some of the other rare side effects associated with GHRP-6
- Flu-like symptoms
- Joint Pain
- Water Retention
- Reduction of touch sensitivity
- Numbness and Tingling
- Bone Weakness
As aforementioned, these GHRP-6 side effects are often dose-dependent and only affect a very small percentage of patients.
Clinical studies and research
- J Clin Endocrinol Metab. 1998 Apr;83(4):1186-9.Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation.Pandya N1, DeMott-Friberg R, Bowers CY, Barkan AL, Jaffe CA. http://press.endocrine.org/doi/10.1210/jcem.83.4.4711?url_ver=Z39.882003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
- Growth hormone secretagogues: mechanism of action and use in aging.Fuh VL1, Bach MA.http://www.sciencedirect.com/science/article/pii/S1096637498803171
- Growth hormone secretagogues: the clinical future.Micic D1, Casabiell X, Gualillo O, Pombo M, Dieguez C, Casanueva FF. http://www.karger.com/?DOI=53159
- Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers.
Cabrales A1, Gil J, Fernandez E, Valenzuela C, Hernandez F, Garcia I, Hernandez A, Besada V, Reyes O, Padron G, Berlanga J, Guillian G, Gonzจขlez LJ.http://www.sciencedirect.com/science/article/pii/S0928098712003880
- Growth Horm IGF Res. 2015 Apr;25(2):59-65. doi: 10.1016/j.ghir.2014.12.005. Epub 2014 Dec 20.
Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies.
Stanley TL1, Grinspoon SK2.http://www.growthhormoneigfresearch.com/article/S1096-6374(14)00120-8/abstract