MELANOTAN II – MT2
What is Melanotan II – MT2?
Human-made analogues of the alpha-melanocyte stimulating hormone have been made for human use. Melanotan I (afamelanotide) is a man-made analogue of alpha-MSH. It is a linear 13 amino acid peptide created at the Arizona Cancer Centre at the University of Arizona to cause skin tanning as a protection against skin cancer (Dorr et al. 2000, Ugwu et al.). It was approved on May 5, 2010, by the Italian Medicines Agency as a medication to induce protective skin pigmentation in the disease erythropoietic protoporphyria. It has minimal effects on sexuality. Melanotan II is another analogue of alpha-MSH. It is a circular, shortened version of Melanotan I, also created at the Arizona Cancer Centre (Dorr et al. 1996, 2004). It is 1,000 times more potent than alpha-MSH. This hormone also provides a therapeutic tan to lower the risk of skin cancer (Lan et al. 1994, Abdel-Malek et al. 2006). There is evidence that it also decreases food intake and body fat mass (Choi et al. 2003). Like Melanotan I, it is administered by injection into the fat beneath the skin. It is a potent stimulant of sexual arousal in man and women. While Melanotan II was developed in the 1980’s, its use is still relatively new. Earliest reports of patient use dates back to 2003. It’s not possible to know the long-term side effects of any product until many individuals have used it over an extended period. However, reports and detailed logs from people using the product consistently for the past 5-6 years indicate that there are no documented adverse long-term side effects of Melanotan II usage. A search of thousands of users via blogs, online forums and social sites revealed that the overall response to Melanotan II was that it is safe. Users have reported no serious adverse consequences. Protecting our skin from the ravages of UV radiation and the resulting development of melanoma, should be priority with sun exposure. Regardless of skin type, and climate, Melanotan II is a viable solution, protecting those who use it from UV damage whilst offering an alternative tanning solution with far less risk and protective mechanisms Molecular Weight: 1024.180 Molecular Formula:C50H69N15O9 Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Safe tanning and the use of Melanotan II – UV protection?
Benefits of Melanotan II - MT2
- Safe Tanning
- Protective Mechanism Against UV Damage
- Positive effect on libido
- Mild positive fat-mobilising effect
Effects of Melanotan II - MT2
- Analogue of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH)
- Melanotan II plays a role in stimulating melanogenesis (tanning) ultimately providing a protective buffer against UV Rays
- Melanocytes increase the production and secretion of the hormone melanin which is responsible for skin pigmentation.
The discovery of Melanotan II - MT2
Melanotan II was created / developed at the University of Arizona. The goal in its development was to provide a safe ‘sun” tan, without sun exposure or the need for UV radiation. THE PEPTIDE SCIENCE OF MELANOCORTINS
- Melanocortins are a group of peptides (short chains of amino acids)
- ACTH, beta-endorphins, alpha-melanocyte stimulating hormone (alpha-MSH), beta-MSH and gamma-MSH.
- They are all partitioned from a large precursor peptide called pro-opiomelanocortin (POMC).
- The three melanocyte stimulating hormones (collectively called MSH or intermedins) are a class of peptide hormones produced in the intermediate lobe of the pituitary gland, located immediately beneath the brain.
- They stimulate pigment cells (melanocytes) in the skin and hair to manufacture and release melanin which leads to the darkening of skin and hair.
- Alpha-MSH is the most abundant MSH, and the most active involved in skin pigmentation.
- MSH also has effects on the brain resulting in decreased hunger and increased libido.
Melanotan II side effects
Occasional side effects include:
- Facial flushing
- Mild nausea
- Loss of appetite
- May increase the darkness of moles and freckles. (This fades once the medication is ceased.)
- Redheads produce a natural variant of melanin (pheomelanin) that is yellowish-red. They will achieve a different shade of tan.
These side effects usually only last for a couple of hours after the injection and typically only occur after the first few injections, after which they do not happen again unless a long break is taken. To reduce the occurrence of side effects
- Take your dose just before bedtime
- It is preferable to have eaten 1-2 hours before treatment (i.e. not on an empty stomach).
- If you are sensitive, you could also take an anti-histamine two hours before the injection.
Positive Side Effects:
- Increases in sex drive for men and women
- Healthier erections for men, particularly in the mornings
- Women noticed stimulation throughout the day.
- Noticeable fat burning properties
- Deeper accelerated tanning but less risk of getting sunburn.
Melanotan II – MT2 Clinical studies and references
- Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets. van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RA, la Fleur SE. Front Behav Neurosci. 2015 Dec 24;9:358. doi: 10.3389/fnbeh.2015.00358. eCollection 2015. PMID: 26733840
- Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Wessells H, Levine N, Hadley ME, Dorr R, Hruby V. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9. PMID: 11035391
- Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Life Sci. 1996;58(20):1777-84. PMID: 8637402
- Melanocortin receptors, melanotropic peptides and penile erection. King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Curr Top Med Chem. 2007;7(11):1098-1106. PMID: 17584130